Cell culture, stem cell characterization, and karyotype analysis. GRs are designed to communicate information in a visually appealing representation of the current state of research on a specific topic. Please note an open access fee is payable for publication in Data in Brief. The function of HSCs gradually changes during aging. Please check the relevant section in this Guide for Authors for more details. Open access Please visit our Open Access page for more information. The use of stem cells to model neurological diseases in vitro and provide a source of cells for transplantation is an extremely active area of research. These cells can be derived from any part of the body, for example, stem cells from the brain, muscle, bone marrow, etc. The address at which the author actually did the work must be retained as the main, affiliation address. Genome data from sweet and grain sorghum (Sorghum bicolor). Manuscripts reporting studies involving human participants, human data or human tissue must: Studies involving animals must include a statement on ethics approval and for experimental studies involving client-owned animals, authors must also include a statement on informed consent from the client or owner. ), should also be given. For example: Hao Z, AghaKouchak A, Nakhjiri N, Farahmand A. Role of the funding source You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. Please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. We are always looking for ways to improve customer experience on Elsevier.com. Permitted third party reuse of open access articles is determined by the author's choice of user license. Any such submission is subject to all of the journal's usual procedures, with peer review handled independently of the relevant editor and their research groups. It should contain high enough quality figures for refereeing. Centeno-Schultz Clinic RSS Feed This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. SJR is a prestige metric based on the idea that not all citations are the same. All manuscripts must include an ‘Availability of data and materials’ statement. Authors are requested to provide institutional email addresses. PSC is scientific journal that overlays the study of Cancer stem cells, Stem cell therapy, Stem-cell transplantation, human embryonic stem cells, Neural stem cells, Murine . This should state clearly the main conclusions and include an explanation of their relevance or importance to the field. present a title that includes, if appropriate, the study design e.g. Found inside – Page 9number of stem cells, by the millions, are found in adipose, or fat tissue. • Adult stem cells—Also referred to as somatic cells, adult stem cells include any stem cell other than an egg or sperm cell in the female or male, respectively ... The arrival and development of induced pluripotent stem cells (iPSCs), thanks to Dr. Yamanaka and other stem cell researchers (Takahashi & Yamanaka, 2006), provided new possibilities to cell therapy and regenerative medicine. A tumor originates from a normal cell that has undergone tumorigenic transformation as a result of genetic mutations. Cell death: the significance of apoptosis. Contact details for submission Manuscripts for Stem Cell Research should be submitted via the journal's online submission and editorial system, https://www.editorialmanager.com/SCR. Bone Marrow Stem Cells cells originated from bone marrow. Found inside – Page 32Quinones-Hinojosa A, Sanai N, Soriano-Navarro M et al (2006) Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J Comp Neurol 494:415–434. During aging, heterogeneity of HSCs changes, contributing to the deterioration of the immune system. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology. The two essential characteristics of stem cells include . In one of the first studies aimed at revealing shared gene expression patterns, Chang and associates [] collected large-scale data sets that had been acquired from ES cells or adult stem cells, and constructed a gene-module map.From the initial gene-module map, two modules (gene sets) that distinguish ES cells (the ESC-like module) and adult stem cells (the . Copyright © 2021 Elsevier, except certain content provided by third parties, Cookies are used by this site. Ten years in public health. 1998. http://www.healthwise.org. Doe, J: Trivial HTTP, RFC2169. Highlights Highlights are mandatory for this journal as they help increase the discoverability of your article via search engines. Data statement To foster transparency, we encourage you to state the availability of your data in your submission. Please note that your article will be reviewed again by the new journal. To test the hypothesis that cis-regulatory elements that control fate decisions for all lineages are primed in HSCs, we used ATAC-seq to compare chromatin . Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. Thanks in advance for your time. For supported data repositories a repository banner will automatically appear next to your published article on ScienceDirect. With this initiative, we intend to speed up support for clinical stage candidate stem cell treatments that demonstrate scientific excellence. This book will prove an invaluable resource for basic and applied researchers and clinicians working on the development of new cancer treatments and therapies, providing a timely publication of high quality reviews outlining the current ... RH performed the histological examination of the kidney, and was a major contributor in writing the manuscript. Endothelial and skeletal muscle lineages arise from common embryonic progenitors. Data availability statements can take one of the following forms (or a combination of more than one if required for multiple datasets): More examples of template data availability statements, which include examples of openly available and restricted access datasets, are available here. First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the ... Since leukemic stem cells (LSCs) or cancer stem cells (CSCs) were found in acute myeloid leukemia (AML) in 1997, extensive studies have been contributed to identification and characterization of such cell populations in various tissues. Overview. Diseases of Stem Cells: These papers could be submitted as full length or brief reports. Please note that individual figure files larger than 10 MB must be uploaded separately. Do not annotate any corrections on a previous version. If you do not have any competing interests, please state "The authors declare that they have no competing interests" in this section. If quoting directly from a previously published method, use quotation marks and also cite the source. Commentaries should be no longer than 1000 words in length and should contain no more than 10 references and no more than 1 display item (boxes . If you wish to co-submit a data note describing your data to be published in BMC Research Notes, you can do so by visiting our submission portal. Cell Stem Cell 的ISSN是 1934-5909 。. iPSCs are derived from somatic cells that are reprogrammed back into an embryonic-like pluripotent state by forced expression of key transcription factors . 2000; doi:10.1007/s801090000086. Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Found inside – Page 160High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping. Cell Stem Cell 2018, 22, 929–940. [CrossRef] [PubMed] 10. Cruz, N.M.; Song, X.; ... Praise from the reviews: "...a highly readable and useful book... A notable feature of the book is its air of openness and honesty... This book... will help many to navigate the uncharted waters of human embryonic stem cell biology. Many recent studies have investigated stem cell-based therapies using ectopic multipotent stem cells, such as MSCs, adipose-derived stem cells, and hematopoietic stem cells for various CNS disorders, including ischemic stroke [18,49,50]. All sources of funding for the research reported should be declared. You should not send the form to us on submission, but we may request to see a copy at any stage (including after publication). Video and animation files supplied will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect. Submission checklist You can use this list to carry out a final check of your submission before you send it to the journal for review. Journal abbreviations source Journal names should be abbreviated according to the List of Title Word Abbreviations. Background Ovarian cancer is a complicated malady associated with cancer stem cells (CSCs) contributing to 238,700 estimated new cases and 151,900 deaths per year, worldwide. They should also not contain any figures or tables. Any subsection may be given a brief heading. Using a KRT5-CreERT2 transgenic mouse line for lineage tracing, we show that basal cells generate differentiated cells during postnatal growth and in the adult during both steady state and epithelial repair. Cover submission guidelines After acceptance, authors may be invited to submit potential cover images related to their manuscript. GRs cannot include unpublished data, new hypotheses, formal mathematical models, or meta-analysis. Stem Cell Therapy Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. Present the authors' affiliation addresses (where the actual work was done) below the names. A brief description of each article type is provided below. Stem cells are defined by their ability to self-renew and to generate progenitor cells that can subsequently divide and differentiate into the different types of cells of a particular tissue [].There are two main types of naturally occurring stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found . During normal development primordial germ cells (PGCs) derived from the epiblast are the precursors of spermatogonia and oogonia. The role of the funding body in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript should be declared. The Editor is responsible for the final decision regarding acceptance or rejection of articles. Color artwork Please make sure that artwork files are in an acceptable format (TIFF (or JPEG), EPS (or PDF) or MS Office files) and with the correct resolution. Found inside – Page 84Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium. Stem Cells. 2005;23:315–23. 8. Levenstein ME, Ludwig TE, Xu RH, Llanas RA, Van DenHeuvel- Kramer K, Manning D, et al. All data generated or analysed during this study are included in this published article [and its supplementary information files]. Cookie Notice
Stem cells are human cells that can be developed and differentiated into other cell types. Induced Pluripotent Stem Cells The stem cells that can be generated from . This study strongly suggests that iSCs, which share several traits with MSCs, are locally induced in the . Elsevier supports responsible sharing Find out how you can share your research published in Elsevier journals. Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue-specific . In: The dictionary of substances and their effects. Please switch off the 'Track Changes' option in Microsoft Office files as these will appear in the published version. We would like to ask you for a moment of your time to fill in a short questionnaire, at the end of your visit. This transformed cell is the cell-of-origin for the tumor. Author Summary The Dmrt1 gene is a deeply conserved gonadal regulator that is expressed in all mitotic germ cells of the mouse, including spermatogonial stem cells (SSCs). International review of cytology. beta-Globin-expressing definitive erythroid progenitor cells generated from embryonic and induced pluripotent stem cell-derived sacs. ftp://ftp.isi.edu/in-notes/rfc2169.txt (1999). You will be notified via email when your preprint is posted online and a Digital Object Identifier (DOI) is assigned. A manuscript of high intrinsic quality may be returned if it seems better suited to a more specialized journal. • For Word submissions only, you may still provide figures and their captions, and tables within a single file at the revision stage. • Indicate per figure if it is a single, 1.5 or 2-column fitting image. Only when your paper is at the revision stage, will you be requested to put your paper in to a 'correct format' for acceptance and provide the items required for the publication of your article.To find out more, please visit the Preparation section below. Note this section should not be used to describe any competing interests. In culture, PGCs can be induced to dedifferentiate to pluripotent embryonic germ (EG) cells in the presence of various growth factors. Declaration of competing interest All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Privacy Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors.If preferred, you can still choose to annotate and upload your edits on the PDF version. Elsevier Researcher Academy Researcher Academy is a free e-learning platform designed to support early and mid-career researchers throughout their research journey. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge, that these figures will appear in color online (e.g., ScienceDirect and other sites) in addition to color reproduction in print. Please use initials to refer to each author's contribution in this section, for example: "FC analyzed and interpreted the patient data regarding the hematological disease and the transplant. This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells. Contributions from leading authorities Informs and updates on all the latest developments in the field The environment is similar to MS Word: in addition to editing text, you can also comment on figures/tables and answer questions from the Copy Editor. The epigenetic mechanisms regulating the multilineage ability, or multipotency, of HSCs are not well understood. The first journal issue that you'll receive is the last published issue before your purchase plus all issues published in the 12-, 24- or 36-month period starting from the date of purchase. http://dx.doi.org/10.6084/m9.figshare.853801, http://tumor.informatics.jax.org/mtbwi/index.do, Sign up for article alerts and news from this journal, Source Normalized Impact per Paper (SNIP). For questions on the submission and reviewing process, please visit our Support Center. 2013;11:63. Commentaries are short, narrowly focused articles of contemporary interest and usually take one of two forms: Commentaries should be no longer than 1000 words in length and should contain no more than 10 references and no more than 1 display item (boxes, tables or figures). The individual contributions of authors to the manuscript should be specified in this section. In text citations should appear as “First Author-Year” and bibliography references as “Author(s)-Year-Title-Journal-Volume/Book chapter-Pagination”. This link is in the form of an article DOI link which can be shared via email and social networks. GRs present an opportunity to succinctly showcase your research contributions within a wider overview of recent developments within a field. The Stem Cell Dilemma illuminates everything you need to know about stem cells, and in this new edition the authors have included up-to-date information on scientific advances with iPS cells, clinical trials that are currently underway, ... One aspect is the expression and activity of transposable elements (TEs). You are encouraged to submit your data article for Data in Brief as an additional item directly alongside the revised version of your manuscript. Sitemap. Hematopoietic stem cells (HSCs) have the capacity to differentiate into vastly different types of mature blood cells. Article within a journal (no page numbers). This can be a PDF file or a Word document, in any format or lay-out that can be used by referees to evaluate your manuscript. As a result, stem cell-based therapy has emerged as a new subspecialty in medicine. Footnotes to the text are numbered consecutively; those to tables should be indicated by superscript lower-case letters (or asterisks for significance values and other statistical data). Lab resources: Peer reviewed manuscript which details the establishment of new pluripotent stem cell lines derived from embryos, generated by SCNT and reprogramming or the establishment of genetically modified stem cell sub-lines. This transformed cell is the cell-of-origin for the tumor. on a preprint server will not count as prior publication (see 'Multiple, redundant or concurrent publication' for more information). Found inside – Page 91(2011) Immunogenicity of induced pluripotent stem cells. Nature. 474:7350:212-215. 7. Araki, R, et al. (2013) Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells. Nature. Found inside – Page 22Stem Cells 19(3):180–192 Billon N, Monteiro MC, Dani C (2008) Developmental origin of adipocytes: new insights into a pending question. Biol Cell 100(10):563–575 Brighton CT, Lorich DG, Kupcha R et al (1992) The pericyte as a possible ... Doe J. Frequency 4 posts / quarter Since - Jan 2014 View Latest Posts ⋅ Get Email Contact. Co-published data notes will be linked to the research article the data support (example). To calculate the five-year Impact Factor, citations are counted to the previous five years and divided by the source items published in those years. Stem cells are versatile in that they can be used to fix damaged tissues. This responsibility includes answering any future queries about Methodology and Materials. Cookie Settings, Terms and Conditions MSCs have been demonstrated to be involved in drug resistance in tumor. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. Data references should include the following elements: author name(s), dataset title, data repository, version (where available), year, and global persistent identifier. Stem cells hold great promise for cell therapy because of their proliferation and differentiation potential. You can view Example Graphical Abstracts on our information site.Authors can make use of Elsevier's Illustration Services to ensure the best presentation of their images and in accordance with all technical requirements. Here, we made an attempt to scrutinize evidences that indicate the role of stem cells in tumorigenesis and metastasis, and cancer relapse. However, several cellular aspects are currently underutilized in single cell studies. Web references As a minimum, the full URL should be given and the date when the reference was last accessed. Cell Stem Cell. These guidelines are meant as a point of reference to help identify appropriate language but are by no means exhaustive or definitive. Electronic artwork General points• Make sure you use uniform lettering and sizing of your original artwork. Citation in text Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Although some have earned approval from the Food and Drug Administration, most have not, and many of these unapproved interventions have led to life-threatening infections, chronic pain, and even death. The abstract should state briefly the purpose of the research, the principal results and major conclusions. Methods that are already published should be summarized, and indicated by a reference. If your data is unavailable to access or unsuitable to post, you will have the opportunity to indicate why during the submission process, for example by stating that the research data is confidential. The ISC compartment is also closely associated with a sub-epithelial compartment that contains multiple types of mesenchymal . All contributions will be initially assessed by the editor for suitability for the journal. We previously showed that Dmrt1 controls the mitosis/meiosis switch in differentiating mouse spermatogonia. Nonlinear adjustments (e.g. How MSCs contribute to radiotherapy resistance of HCC is still indistinct. We recommend avoiding the use of descriptors that refer to personal attributes such as age, gender, race, ethnicity, culture, sexual orientation, disability or health condition unless they are relevant and valid. 2011. http://dx.doi.org/10.5524/100012. Further information on the preparation of electronic artwork. The Editor's decision is final. Topics covered include embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, stem cell differentiation, epigenetics, stem cell genomics and systems biology, genome reprogramming, cancer stem cells, stem cell niches, stem-cell-based disease models, nuclear . At the minimum, at least the corresponding author and submitting author should provide an institutional email address. Data in Brief You have the option of converting any or all parts of your supplementary or additional raw data into a data article published in Data in Brief. On this page, we provide tools and guidelines for creating high-quality figures and images that are optimized for submission to Cell Press journals, including information on data processing and obtaining permissions for reprinted images. Superscript Arabic numerals are used for such footnotes. Cell Biology 2021 Virtual Event will continue to create a valuable platform for inspiring global and interdisciplinary collaboration . Stem Cells Dev 20:1639-1647. Here we shift this paradigm by uncovering how adult MuSC behavior is affected by the expression of a subset of EC . GigaScience Database. It is a brief summary (approximately 100 words) describing the overarching significance of the article and clearly defining its potential impact. 3rd ed. Human pluripotent stem cells (hPSCs) provide powerful models for studying cellular differentiations and unlimited sources of cells for regenerative medicine. One author has been designated as the corresponding author with contact details:• E-mail address• Full postal address, Further considerations• Manuscript has been 'spell checked' and 'grammar checked'• All references mentioned in the Reference List are cited in the text, and vice versa• Permission has been obtained for use of copyrighted material from other sources (including the Internet)• A competing interests statement is provided, even if the authors have no competing interests to declare• Journal policies detailed in this guide have been reviewed• Referee suggestions and contact details provided, based on journal requirements. Top Curr Chem. This statement should not contain references and should avoid numbers, measurements . Oxford: Blackwell Science; 1998. Subdivision - numbered sections Divide your article into clearly defined and numbered sections. See also the section on Electronic artwork. Ensure consistency of abbreviations throughout the article. Springer Nature. Please acknowledge anyone who contributed towards the article who does not meet the criteria for authorship including anyone who provided professional writing services or materials. I INTRODUCTION. This may include details about the authors' qualifications, current positions they hold at institutions or societies, or any other relevant background information. Web links and URLs: All web links and URLs, including links to the authors' own websites, should be given a reference number and included in the reference list rather than within the text of the manuscript. See our editorial policies for a full explanation of competing interests. The genesis of stem cells is followed by laboratory steps of controlled stem cell culturing and derivation. With the corresponding text in the Availability of data and materials statement: The datasets generated during and/or analysed during the current study are available in the [NAME] repository, [PERSISTENT WEB LINK TO DATASETS]. The second form is more editorial in nature and covers an aspect of an issue that is relevant to the journal's scope, for example discussion of the impact of new technology on research and treatment. Crossref, Medline, Google Scholar; 15. The role of the niche in maintaining stem cells has been shown in several systems. If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. Web references can be listed separately (e.g., after the reference list) under a different heading if desired, or can be included in the reference list. For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication. Preprint posting on SSRN In support of Open Science, this journal offers its authors a free preprint posting service. To request such a change, the Editor must receive the following from the corresponding author: (a) the reason for the change in author list and (b) written confirmation (e-mail, letter) from all authors that they agree with the addition, removal or rearrangement. Slifka MK, Whitton JL. Under this initiative, we will provide funding for eligible projects that are completing late stage . All instructions for proofing will be given in the e-mail we send to authors, including alternative methods to the online version and PDF.We will do everything possible to get your article published quickly and accurately. For more detailed instructions please visit our video instruction pages. Before you submit your manuscript to Stem Cell Research & Therapy, please ensure you have read and noted the below: . Please note that individual names may not be present in the PubMed record at the time a published article is initially included in PubMed as it takes PubMed additional time to code this information. In this study, we revisited mouse HSC compartment and its transcriptional plasticity during aging at unicellular scale. If you are unsure whether you or any of your co-authors have a competing interest please contact the editorial office. The first form is a discussion of an article or trial that was recently published or that is soon to be published, and that is interesting enough to warrant further comment or explanation. A combined Results and Discussion section is often appropriate. Please use the authors initials to refer to each authors' competing interests in this section. Manage cookies/Do not sell my data we use in the preference centre. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor. Frumin AM, Nussbaum J, Esposito M. Functional asplenia: demonstration of splenic activity by bone marrow scan. Stem Cell Research is dedicated to publishing high-quality manuscripts focusing on the biology and applications of stem cell research. Both corresponding and co-authors may order offprints at any time via Elsevier's Author Services. Cells are the building blocks of life and some cells (stem cells) have the ability to produce other cells through the processes of cell division and cell differentiation. Rohrmann S, Overvad K, Bueno-de-Mesquita HB, Jakobsen MU, Egeberg R, Tjønneland A, et al. Lipopolysaccharides (LPS) and Shiga Toxin (Stx) are the two main bacterial toxins present in Hemolytic Uremic Syndrome (HUS) that cause endothelial damage. If abbreviations are used in the text they should be defined in the text at first use, and a list of abbreviations should be provided.
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